Hypogonadotropic hypogonadism (HH) is a form of hypogonadism that is due to a problem with the pituitary gland or hypothalamus.
Gonadotropin deficiency; Secondary hypogonadism
HH is caused by a lack of hormones that normally stimulate the ovaries or testes: follicle stimulating hormone (FSH) and luteinizing hormone (LH).
Normally, the hypothalamus in the brain releases gonadotropin-releasing hormone (GnRH).
There are several causes of HH:
Kallmann syndrome is an inherited form of HH that typically occurs with a loss of smell.
Tests that may be done include:
Treatment depends on the source of the problem, but may involve:
The right hormone treatment will cause puberty to start and may restore fertility. If the condition begins after puberty or in adulthood, symptoms will often improve with treatment.
Call your health care provider if:
Styne DM, Grumbach MM. Puberty: Ontogeny, neuroendocrinology, physiology, and disorders. In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 25.